Symbol
Name
ID

Cdkn1b
cyclin dependent kinase inhibitor 1B
MGI:104565

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes	Elevated circulating growth hormone concentration	Pituitary adenoma	Carcinoid tumor	Pancreatic endocrine tumor
Disease(s) Associated with CDKN1B
multiple endocrine neoplasia type 4

Mouse Phenotypes

abnormal neuron differentiation

abnormal neuronal migration

increased pituitary gland weight

enlarged pituitary gland

pituitary gland hyperplasia

abnormal pituitary intermediate lobe morphology

pituitary intermediate lobe hyperplasia

increased pituitary gland tumor incidence

increased pituitary adenoma incidence

increased cochlear hair cell number

increased cochlear inner hair cell number

increased cochlear outer hair cell number

increased brain weight

abnormal epithalamus morphology

abnormal hippocampus morphology

abnormal cerebral cortex morphology

abnormal Muller cell morphology

increased amacrine cell number

abnormal retina photoreceptor morphology

Availability

Mouse Genotype

Cdkn1b^tm1Ako/Cdkn1b^tm1Ako

Cdkn1b^tm1Kin/Cdkn1b^tm1Kin

Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf

Cdkn1b^tm3Mlf/Cdkn1b^tm3Mlf

Cdkn1b^tm1Mlf/Cdkn1b⁺

Cdkn1b^tm2Mlf/Cdkn1b^tm2Mlf
Tg(Pomc1-cre)1Mlf/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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